Located along the Mississippi River in eastern Missouri, Ste. Genevieve County is a destination rich in history, culture, and natural beauty. The county is especially known for its well-preserved French colonial heritage, with historic architecture that reflects its early European roots.

The county seat, Ste. Genevieve, holds a unique place in American history as the oldest permanent European settlement west of the Mississippi River. Visitors can explore its charming historic district, which offers a glimpse into the region’s colonial past.

In addition to its historical and natural attractions, the county is part of Missouri’s growing wine region. Rolling hills dotted with vineyards create a picturesque landscape, while local wineries offer visitors the opportunity to sample a variety of locally produced wines and enjoy the area's rural charm.