Holt County is located in the northwestern corner of Missouri along the Missouri River. Agriculture plays a central role in the local economy, with corn production being especially important. The county borders Nebraska to the west.
The county seat, Oregon, is a small community that serves as the center of county government. Along the western edge of the county, the distinctive Loess Hills rise above the landscape. These unique hills were formed by wind-deposited silt thousands of years ago.
Outdoor enthusiasts often visit Big Lake State Park for fishing, birdwatching, and other recreational activities. The county also features sites associated with the historic Lewis and Clark Expedition.






