| County Name | Mississippi County |
| County Seat | Blytheville and Osceola (dual seats) |
| Etymology | Named after the Mississippi River, which forms the eastern border of the county |
| Cities, Towns, and Communities | Blytheville, Osceola, Manila, Gosnell, Leachville, Luxora, Wilson, Keiser, Joiner, Bassett, Burdette, Etowah, Dyess |
| Interstates and Highways | Interstate 55, U.S. Route 61, U.S. Route 63, U.S. Route 77, State Route 14, State Route 18, State Route 119, State Route 135 |
| FIPS Code | 05-093 |
| Total Area (Land and Water) | 920 square miles (Land: 901 sq mi, Water: 19 sq mi) |
| Adjacent Counties (and Direction) | Dunklin County, Missouri (Northwest), Pemiscot County, Missouri (North), Dyer County, Tennessee (Northeast), Lauderdale County, Tennessee (East), Tipton County, Tennessee (Southeast), Crittenden County (South), Poinsett County (Southwest), Craighead County (West) |
| Time Zone | Central Standard Time (CST) |
| State | Arkansas |
| Coordinates | 35.9059° N, 89.8871° W |
| Major Landmarks | Big Lake National Wildlife Refuge, Arkansas Northeastern College, Mississippi County Courthouse, Historic Greyhound Bus Station, Eaker Air Force Base (former) |
| Population | Approximately 40,000 |